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1

Membrane transporters in drug development

Giacomini, Kathleen M., Huang, Shiew-Mei, Tweedie, Donald J., Benet, Leslie Z., Brouwer, Kim L.R., Chu, Xiaoyan, Dahlin, Amber, Evers, Raymond, Fischer, Volker, Hillgren, Kathleen M.

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 646 KB

english, 2010

2

Predicting Drug–Drug Interactions: An FDA Perspective

Lei Zhang, Yuanchao (Derek) Zhang, Ping Zhao, Shiew-Mei Huang

Journal:

The AAPS Journal

Year:

2009

Language:

english

File:

PDF, 155 KB

english, 2009

3

Fifty-Eight Years and Counting: High-Impact Publishing in Computational Pharmaceutical Sciences and Mechanism-Based Modeling

Amidon, Gregory E., Anderson, Bradley D., Balthasar, Joseph P., Bergstrom, Christel A.S., Huang, Shiew-Mei, Kasting, Gerald, Kesisoglou, Filippos, Khinast, Johannes G., Mager, Donald E., Roberts, Chri

Journal:

Journal of Pharmaceutical Sciences

Year:

2018

Language:

english

File:

PDF, 308 KB

english, 2018

4

Pharmacokinetics of drugs in blood I. Unusual distribution of gentamicin

Myung G. Lee, Mei-Ling Chen, Shiew-Mei Huang, Win L. Chiou

Journal:

Biopharmaceutics & Drug Disposition

Year:

1981

Language:

english

File:

PDF, 335 KB

english, 1981

5

Drug interactions evaluation: An integrated part of risk assessment of therapeutics

Lei Zhang, Kellie S. Reynolds, Ping Zhao, Shiew-Mei Huang

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 515 KB

english, 2010

6

CYP-Mediated Therapeutic Protein-Drug Interactions

Dr Jang-Ik Lee, Lei Zhang, Angela Y. Men, Leslie A. Kenna, Shiew-Mei Huang

Journal:

Clinical Pharmacokinetics

Year:

2010

Language:

english

File:

PDF, 195 KB

english, 2010

7

New Era in Drug Interaction Evaluation: US Food and Drug Administration Update on CYP Enzymes, Transporters, and the Guidance Process

Huang, Shiew-Mei, Strong, John M., Zhang, Lei, Reynolds, Kellie S., Nallani, Srikanth, Temple, Robert, Abraham, Sophia, Habet, Sayed Al, Baweja, Raman K., Burckart, Gilbert J., Chung, Sang, Colangelo,

Journal:

Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 90 KB

english, 2008

8

Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

Wu, Fang, Gaohua, Lu, Zhao, Ping, Jamei, Masoud, Huang, Shiew-Mei, Bashaw, Edward D., Lee, Sue-Chih

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 915 KB

english, 2014

9

Utility of a physiologically–based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug–drug–disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice

Joseph A. Grillo, Ping Zhao, Julie Bullock, Brian P. Booth, Min Lu, Kathy Robie-Suh, Eva Gil Berglund, K. Sandy Pang, Atiqur Rahman, Lei Zhang, Lawrence J. Lesko, Shiew-Mei Huang

Journal:

Biopharmaceutics & Drug Disposition

Year:

2012

Language:

english

File:

PDF, 535 KB

english, 2012

10

Etintidine-theophylline interaction study in humans

Shiew-Mei Huang, Howard S. Weintraub, Thomas B. Marriott, Barbara Marinan, Robert Abels, Phillip T. Leese

Journal:

Biopharmaceutics & Drug Disposition

Year:

1987

Language:

english

File:

PDF, 446 KB

english, 1987

11

Simultaneous monitoring of bemoradan pharmacokinetics and hemodynamics in mongrel dogs

Dr. Shiew-Mei Huang, Robert Falotico, Barbara Haertlein, Ian L. Smith

Journal:

Biopharmaceutics & Drug Disposition

Year:

1992

Language:

english

File:

PDF, 411 KB

english, 1992

12

A pharmacokinetic evaluation of HIV protease inhibitors, cyclic ureas, in rats and dogs

Y. Nancy Wong, Deborah L. Burcham, Philip L. Saxton, Susan Erickson-Viitanen, Mary F. Grubb, Check Y. Quon, Shiew-Mei Huang

Journal:

Biopharmaceutics & Drug Disposition

Year:

1994

Language:

english

File:

PDF, 425 KB

english, 1994

13

A sensitive high performance liquid chromatography microassay for bemoradan, a novel cardiotonic agent, in plasma/serum using a semi-automatic liquid/solid extraction sample preparation system—AASP®

Shiew-Mei Huang, Shu-Chean Chien, Soledad C. Flor

Journal:

Biomedical Chromatography

Year:

1990

Language:

english

File:

PDF, 351 KB

english, 1990

14

Pharmacokinetics and bioavailability of etintidine in beagle dogs: Effects of routes of administration, doses, dosage forms, and chronic dosing

Shiew-Mei Huang, Larry S. Abrams, Thomas B. Marriott, Howard S. Weintraub

Journal:

Biopharmaceutics & Drug Disposition

Year:

1988

Language:

english

File:

PDF, 562 KB

english, 1988

15

Clinical pharmacokinetics of etintidine

Shiew-Mei Huang, Howard S. Weintraub, Robert Abels, William Harris, Thomas B. Marriott, John D. Arnold, Joseph Boccagno

Journal:

Biopharmaceutics & Drug Disposition

Year:

1988

Language:

english

File:

PDF, 435 KB

english, 1988

16

Precaution in use of high-pressure liquid chromatographic simultaneous plasma procainamide and N-acetylprocainamide determination

Roger L. Nation, Myung G. Lee, Shiew-Mei Huang, Win L. Chiou

Journal:

Journal of Pharmaceutical Sciences

Year:

1979

Language:

english

File:

PDF, 348 KB

english, 1979

17

High-performance liquid chromatographic determination of a new H2 blocker (ORF 17 910) in plasma

Shiew-Mei Huang, Hale Tran-Phan

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1987

Language:

english

File:

PDF, 330 KB

english, 1987

18

High-performance liquid chromatographic determination of a potent AII receptor antagonist (DMP 811) in plasma

Allison M. Agra, Shiew-Mei Huang

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1993

Language:

english

File:

PDF, 427 KB

english, 1993

19

Determination of XR510, a balanced angiotensin II receptor antagonist, in dog and rat plasma by combined liquid-liquid/solid-phase extraction and high-performance liquid chromatography

Thomas A. Emm, Candice L. Krauthauser, Shiew-Mei Huang

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1996

Language:

english

File:

PDF, 366 KB

english, 1996

20

Chromatography and electrophoresis of creatinine and other guanidino compounds

Shiew-Mei Huang, Yih-Chain Huang

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1988

Language:

english

File:

PDF, 1.27 MB

english, 1988

21

Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential—towards a consensus

Geoffrey T. Tucker, J. Brian Houston, Shiew-Mei Huang

Journal:

British Journal of Clinical Pharmacology

Year:

2001

Language:

english

File:

PDF, 138 KB

english, 2001

22

Nonpeptide angiotensin II receptor antagonists: the discovery of DMP 581 and DMP 811

David J. Carini, Robert J. Ardecky, Carol L. Ensinger, James R. Pruitt, Ruth R. Wexler, Pancras C. Wong, Shiew-Mei Huang, Bruce J. Aungst, Pieter B.M.W.M. Timmermans

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 372 KB

english, 1994

23

Transporters in drug development: advancing on the Critical Path

Huang, Shiew-Mei, Woodcock, Janet

Journal:

Nature Reviews Drug Discovery

Year:

2010

Language:

english

File:

PDF, 161 KB

english, 2010

24

Optimizing Drug Development: Strategies to Assess Drug Metabolism/Transporter Interaction Potential—Toward a Consensus

Geoffrey T. Tucker, J. Brian Houston, Shiew-Mei Huang

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 169 KB

english, 2001

25

Bioavailability and Bioequivalence: An FDA Regulatory Overview

Mei-Ling Chen, Vinod Shah, Rabindra Patnaik, Wallace Adams, Ajaz Hussain, Dale Conner, Mehul Mehta, Henry Malinowski, John Lazor, Shiew-Mei Huang, Don Hare, Lawrence Lesko, Douglas Sporn, Roger Willia

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 137 KB

english, 2001

26

Effects of Structural Modifications on the Intestinal Permeability of Angiotensin II Receptor Antagonists and the Correlation ofIn Vitro, In Situ,andIn VivoAbsorption

Maria D. Ribadeneira, Bruce J. Aungst, Charles J. Eyermann, Shiew-Mei Huang

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 1.11 MB

1996

27

The Effect of Absorption Enhancers on the Oral Absorption of the GP IIB/IIIA Receptor Antagonist, DMP 728, in Rats and Dogs

Deborah L. Burcham, Bruce A. Aungst, Munir Hussain, Mary Ann Gorko, Check Y. Quon, Shiew-Mei Huang

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 698 KB

1995

28

Transport and Metabolic Characterization of Caco-2 Cells Expressing CYP3A4 and CYP3A4 Plus Oxidoreductase

Ming Hu, Yiqi Li, Christine M. Davitt, Shiew-Mei Huang, Kenneth Thummel, Bruce W. Penman, Charles L. Crespi

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.87 MB

1999

29

Effect of St John's wort on the pharmacokinetics of fexofenadine*

Wang, Zaiqi, Hamman, Mitchell A., Huang, Shiew-Mei, Lesko, Lawrence J., Hall, Stephen D.

Journal:

Clinical Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 83 KB

english, 2002

30

AAPS Workshop Report: Strategies to Address Therapeutic Protein–Drug Interactions during Clinical Development

Sandhya Girish, Steven W Martin, Mark C Peterson, Lei K. Zhang, Hong Zhao, Joseph Balthasar, Raymond Evers, Honghui Zhou, Min Zhu, Lewis Klunk, Chao Han, Eva Gil Berglund, Shiew-Mei Huang, Amita Joshi

Journal:

The AAPS Journal

Year:

2011

Language:

english

File:

PDF, 464 KB

english, 2011

31

Application of Pharmacogenomics in Clinical Pharmacology

Huang, Shiew-Mei, Goodsaid, Federico, Rahman, Atiqur, Frueh, Felix, Lesko, Lawrence J.

Journal:

Toxicology Mechanisms and Methods

Year:

2006

Language:

english

File:

PDF, 764 KB

english, 2006

32

PBPK as a tool in regulatory review

Shiew-Mei Huang

Journal:

Biopharmaceutics & Drug Disposition

Year:

2012

Language:

english

File:

PDF, 54 KB

english, 2012

33

Etintidine-propranolol interaction study in humans

Shiew-Mei Huang, Howard S. Weintraub, Thomas B. Marriott, Barbara Marinan, Robert Abels

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1987

Language:

english

File:

PDF, 672 KB

english, 1987

34

Pharmacokinetics and tissue distribution of chlorpheniramine in rabbits after intravenous administration

Shiew-Mei Huang, Win L. Chiou

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1981

Language:

english

File:

PDF, 712 KB

english, 1981

35

Oral absorption and presystemic first-pass effect of chlorpheniramine in rabbits

Shiew-Mei Huang, Yih-Chain Huang, Win L. Chiou

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1981

Language:

english

File:

PDF, 686 KB

english, 1981

36

Enhancement of the intestinal absorption of peptides and nonpeptides

Bruce J. Aungst, Hiroshi Saitoh, Deborah L. Burcham, Shiew-Mei Huang, Shaker A. Mousa, Munir A. Hussain

Journal:

Journal of Controlled Release

Year:

1996

Language:

english

File:

PDF, 1021 KB

english, 1996

37

A High-Performance Liquid Chromatographic Microassay Employing a Liquid–Solid Extraction Technique for Etintidine in Plasma

Shiew-Mei Huang, Elaine Rubin, Thomas B. Marriott

Journal:

Pharmaceutical Research

Year:

1987

File:

PDF, 624 KB

1987

38

Qualification of Biomarkers for Drug Development in Organ Transplantation

Gilbert J. Burckart, Shashi Amur, Federico M. Goodsaid, Lawrence J. Lesko, Felix W. Frueh, Shiew-Mei Huang, Marc W. Cavaille-Coll

Journal:

American Journal of Transplantation

Year:

2008

Language:

english

File:

PDF, 797 KB

english, 2008

39

Scientific and Regulatory Perspectives on Metabolizing Enzyme−Transporter Interplay and Its Role in Drug Interactions: Challenges in Predicting Drug Interactions†

Zhang, Lei, Zhang, Yuanchao, Huang, Shiew-Mei

Journal:

Molecular Pharmaceutics

Year:

2009

Language:

english

File:

PDF, 379 KB

english, 2009

40

Population Pharmacokinetics

Dr He Sun, Emmanuel O. Fadiran, Carolyn D. Jones, Lawrence Lesko, Shiew-Mei Huang, Karen Higgins, Chuanpu Hu, Stella Machado, Samuel Maldonado, Roger Williams, Mohammad Hossain, Ene I. Ette

Journal:

Clinical Pharmacokinetics

Year:

1999

Language:

english

File:

PDF, 202 KB

english, 1999

41

Ondansetron can enhance cisplatin-induced nephrotoxicity via inhibition of multiple toxin and extrusion proteins (MATEs)

Li, Qing, Guo, Dong, Dong, Zhongqi, Zhang, Wei, Zhang, Lei, Huang, Shiew-Mei, Polli, James E., Shu, Yan

Journal:

Toxicology and Applied Pharmacology

Year:

2013

Language:

english

File:

PDF, 670 KB

english, 2013

42

Principles of Clinical Pharmacology || Pharmacogenomic Mechanisms of Drug Toxicity

Huang, Shiew-Mei

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

43

Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations

Hsu, Vicky, L. T. Vieira, Manuela, Zhao, Ping, Zhang, Lei, Zheng, Jenny Huimin, Nordmark, Anna, Berglund, Eva Gil, Giacomini, Kathleen M., Huang, Shiew-Mei

Journal:

Clinical Pharmacokinetics

Year:

2014

Language:

english

File:

PDF, 632 KB

english, 2014

44

The utility of modeling and simulation in drug development and regulatory review

Huang, Shiew-Mei, Abernethy, Darrell R., Wang, Yaning, Zhao, Ping, Zineh, Issam

Journal:

Journal of Pharmaceutical Sciences

Year:

2013

Language:

english

File:

PDF, 831 KB

english, 2013

45

Scientific Perspectives on Drug Transporters and Their Role in Drug Interactions †

Zhang, Lei, Strong, John M., Qiu, Wei, Lesko, Lawrence J., Huang, Shiew-Mei

Journal:

Molecular Pharmaceutics

Year:

2006

Language:

english

File:

PDF, 197 KB

english, 2006

46

2-Fluoro-4-pyridinylmethyl Analogues of Linopirdine as Orally Active Acetylcholine Release-Enhancing Agents with Good Efficacy and Duration of Action

Earl, Richard A., Zaczek, Robert, Teleha, Christopher A., Fisher, Barbara N., Maciag, Carla M., Marynowski, Maria E., Logue, Andrew R., Tam, S. William, Tinker, William J., Huang, Shiew-Mei, Chorvat,

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 232 KB

english, 1998

47

Clinical pharmacology as a cornerstone of orphan drug development

Bashaw, Edward D., Huang, Shiew-Mei, Coté, Timothy R., Pariser, Anne R., Garnett, Christine E., Burckart, Gilbert, Zhang, Lei, Men, Angela Y., Le, Christine D., Charlab, Rosane, Gobburu, Jogaro V., Le

Journal:

Nature Reviews Drug Discovery

Year:

2011

Language:

english

File:

PDF, 128 KB

english, 2011

48

Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study

Zhao, Ping, Ragueneau-Majlessi, Isabelle, Zhang, Lei, Strong, John M., Reynolds, Kellie S., Levy, Rene H., Thummel, Kenneth E., Huang, Shiew-Mei

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 432 KB

english, 2009

49

A Regulatory Science Perspective on Warfarin Therapy: A Pharmacogenetic Opportunity

Kim, Myong-Jin, Huang, Shiew-Mei, Meyer, Urs A., Rahman, Atiqur, Lesko, Lawrence J.

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 790 KB

english, 2009

50

Authors' Response

Huang, Shiew-Mei, Lesko, Lawrence J.

Journal:

Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 65 KB

english, 2009